The horrors kids go through thinking that a black hole could just suddenly appear in our solar system and eat everything.

Are there some big drawbacks that one has to live with switching from LaTeX to Typst or is it generally able to be a full replacement?

It was the same for me. I stopped looking at Logseq the second I saw that it didn’t simply save text files. It shouldn’t really be an issue since Logseq is open source so you won’t lose access to your files but for notes I like the simplicity of plain text files for backup in git, for sharing and for searchability.